It is difficult to find electric guitar set ups that stand out, are unique to you and your sound. Developing "your" sound is paramount for a guitar player in my opinion. However when faced with the same gear options as everyone else, creating a sonic divide between you and the other dude is nearly impossible. The search can lead to endless purchasing of toys in attempts to find some combination of pedals and knobs that creates some sonic that is uniquely you. Not likely to happen.
I found that tearing down my gear and rebuilding it in unorthodox ways can sometimes create sounds that are cool but not familiar to the listener, memorable.
Here is a great vid/articlel about tweakin' the tele in one of my favorite guitar emagazines.